Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.

@article{Kubokura2015DifferentiationinducingFI,
  title={Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.},
  author={Naoya Kubokura and Fumi Takahashi-Yanaga and Masaki Arioka and Tatsuya Yoshihara and Kazunobu Igawa and Katsuhiko Tomooka and Sachio Morimoto and Yoshimichi Nakatsu and Teruhisa Tsuzuki and Yusaku Nakabeppu and Takayuki Matsumoto and Takanari Kitazono and Toshiyuki Sasaguri},
  journal={Journal of pharmacological sciences},
  year={2015},
  volume={127 4},
  pages={446-55}
}
Differentiation-inducing factor-1 (DIF-1) produced by Dictyostelium discoideum strongly inhibits the proliferation of various types of cancer cells by suppression of the Wnt/β-catenin signal transduction pathway. In the present study, we examined the effect of differentiation-inducing factor-3 (DIF-3), a monochlorinated metabolite of DIF-1 that is also produced by D. discoideum, on human colon cancer cell lines HCT-116 and DLD-1. DIF-3 strongly inhibited cell proliferation by arresting the cell… CONTINUE READING