Differentiation-inducing factor-1, a morphogen of dictyostelium, induces G(1) arrest and differentiation of vascular smooth muscle cells.

@article{Miwa2000DifferentiationinducingFA,
  title={Differentiation-inducing factor-1, a morphogen of dictyostelium, induces G(1) arrest and differentiation of vascular smooth muscle cells.},
  author={Yoshikazu Miwa and Toshiyuki Sasaguri and Chika Kosaka and Yoji Taba and Atsushi Ishida and Takeo Abumiya and Yuzuru Kubohara},
  journal={Circulation research},
  year={2000},
  volume={86 1},
  pages={68-75}
}
Differentiation-inducing factor-1 (DIF-1) is a morphogen that induces differentiation of DICTYOSTELIUM: Recently, DIF-1 has been shown to inhibit proliferation and induce differentiation in tumor cells, although the underlying mechanisms remain unknown. In this study, we examined the effects of DIF-1 on the proliferation and differentiation of vascular smooth muscle cells, to explore novel therapeutic strategies for atherosclerosis. DIF-1 nearly completely inhibited DNA synthesis and cell… CONTINUE READING
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