Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change

  title={Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change},
  author={Maria Pilar Alcolea and Philip Greulich and Agnieszka Wabik and Julia Frede and Benjamin D Simons and Philip H Jones},
  journal={Nature Cell Biology},
Multiple cancers may arise from within a clonal region of preneoplastic epithelium, a phenomenon termed ‘field change’. However, it is not known how field change develops. Here we investigate this question using lineage tracing to track the behaviour of scattered single oesophageal epithelial progenitor cells expressing a mutation that inhibits the Notch signalling pathway. Notch is frequently subject to inactivating mutation in squamous cancers. Quantitative analysis reveals that cell… CONTINUE READING
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