Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening

@inproceedings{Boissart2013DifferentiationFH,
  title={Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening},
  author={Claire Boissart and Aur{\'e}lie Poulet and Pauline Georges and H{\'e}l{\`e}ne Darville and E Julita and Richard Delorme and Thomas Bourgeron and Marc Peschanski and Alexandra Benchoua},
  booktitle={Translational Psychiatry},
  year={2013}
}
Cortical neurons of the superficial layers (II-IV) represent a pivotal neuronal population involved in the higher cognitive functions of the human and are particularly affected by psychiatric diseases with developmental manifestations such as schizophrenia and autism. Differentiation protocols of human pluripotent stem cells (PSC) into cortical neurons have been achieved, opening the way to in vitro modeling of neuropsychiatric diseases. However, these protocols commonly result in the… CONTINUE READING