Differentiation-dependent switch in protein kinase C isoenzyme activation by FcgammaRI, the human high-affinity receptor for immunoglobulin G.

@article{Melendez1999DifferentiationdependentSI,
  title={Differentiation-dependent switch in protein kinase C isoenzyme activation by FcgammaRI, the human high-affinity receptor for immunoglobulin G.},
  author={Alirio J. Melendez and Margaret M Harnett and Janet M. Allen},
  journal={Immunology},
  year={1999},
  volume={96 3},
  pages={457-64}
}
Aggregation of receptors for the constant region (Fc) of immunoglobulin G on myeloid cells results in endocytosis or phagocytosis and cellular activation. Previous work has shown, using the cell line U937, that the high-affinity immunoglobulin G receptor, FcgammaRI, activates alternate intracellular signalling pathways depending on the cell differentiation state, which results in a marked change in the nature of calcium transients within the cell. Here, we show that protein kinase C (PKC) is… CONTINUE READING
Highly Cited
This paper has 48 citations. REVIEW CITATIONS