Differentiation-dependent p53 regulation of nucleotide excision repair in keratinocytes.

@article{Li1997DifferentiationdependentPR,
  title={Differentiation-dependent p53 regulation of nucleotide excision repair in keratinocytes.},
  author={Guoqing Li and Vincent C. Y. Ho and Deanah L Mitchell and Martin J. Trotter and Victor A. Tron},
  journal={The American journal of pathology},
  year={1997},
  volume={150 4},
  pages={
          1457-64
        }
}
The role of the tumor suppressor p53 in repair of ultraviolet light (UV)-induced DNA damage was evaluated using a host-cell reactivation (HCR) assay. HCR determines a cell's ability to repair UV-damaged DNA through reactivation of a transfected CAT reported plasmid. Most UV damage is removed through nucleotide excision repair (NER). Primary murine keratinocytes isolated from p53-deficient and wild-type p53 mice were used in the HCR assay. The NER was reduced in p53-/- keratinocytes as compared… CONTINUE READING

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