Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development.

Abstract

The transcription factor RUNX-1 plays a key role in megakaryocyte differentiation and is mutated in cases of myelodysplastic syndrome and leukemia. In this study, we purified RUNX-1-containing multiprotein complexes from phorbol ester-induced L8057 murine megakaryoblastic cells and identified the ets transcription factor FLI-1 as a novel in vivo-associated… (More)
DOI: 10.1128/MCB.00090-09

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