Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies.

@article{Fur1983DifferentiationBT,
  title={Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies.},
  author={G{\'e}rard Le Fur and Nicolas Vaucher and Michel Perrier and A. Flamier and Jaramillo Benavides and Corinne Renault and Marie Christine Dubroeucq and C. Gu{\'e}r{\'e}my and Alexandra Uzan},
  journal={Life sciences},
  year={1983},
  volume={33 5},
  pages={
          449-57
        }
}
The [3H]PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methyl-propyl)-3-isoquinolinecarboxamide, binding sites in rat cardiac membranes are saturable, with high affinity, specific GABA-independent and correspond to the peripheral type of benzodiazepine. The order of potency of displacing agents was: PK 11195 greater than RO5-4864 greater than dipyridamole greater than diazepam greater than clonazepam. The Bmax obtained with [3H]PK 11195 was equivalent of the Bmax obtained with [3H]RO5-4864 in the… CONTINUE READING
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