Differentiation between two biologically distinct classes of group A streptococci by limited substitutions of amino acids within the shared region of M protein-like molecules

@article{Bessen1990DifferentiationBT,
  title={Differentiation between two biologically distinct classes of group A streptococci by limited substitutions of amino acids within the shared region of M protein-like molecules},
  author={Debra E. Bessen and Vincent A. Fischetti},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={172},
  pages={1757 - 1764}
}
Group A streptococci can be categorized into two classes (I and II) based on immunodeterminants contained within a surface-exposed, conserved region (C repeat domain) of the major virulence factor, M protein. Previous studies have shown that several biological properties correlate strongly with streptococcal class, and thus, there is a strong impetus to precisely define the antigenic epitopes unique to class I and II M proteins. Using synthetic peptides, the binding sites of two class I… CONTINUE READING

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Identification of a divergent M protein gene and an M protein related gene family in serotype 49 Streptococcus pyogenes

  • Haanes, .J E, P. P. Cleary
  • J. Bacteriol
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