Differentiation between mu and kappa receptor-mediated effects in opioid drug discrimination: apparent pA2 analysis.

@article{Bertalmio1987DifferentiationBM,
  title={Differentiation between mu and kappa receptor-mediated effects in opioid drug discrimination: apparent pA2 analysis.},
  author={Albert J. Bertalmio and J. H. Woods},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={243 2},
  pages={591-7}
}
Apparent pA2 values for the opioid antagonist, quadazocine, were used to characterize differential involvement of mu and kappa opioid receptors in the discriminative stimulus effects of opioid agonists. Rhesus monkeys were trained to discriminate s.c. injections of either codeine or ethylketazocine from sham injections. In tests of drug generalization, morphine, levorphanol and alfentanil all produced dose-dependent increases in codeine-appropriate responding, and ethylketazocine produced dose… CONTINUE READING