Differentiation between hypoxic and non-hypoxic experimental tumors by dynamic contrast-enhanced magnetic resonance imaging.

@article{Gulliksrud2011DifferentiationBH,
  title={Differentiation between hypoxic and non-hypoxic experimental tumors by dynamic contrast-enhanced magnetic resonance imaging.},
  author={Kristine Gulliksrud and Kirsti Marie \Ovreb\o and Berit S. Mathiesen and Einar K. Rofstad},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2011},
  volume={98 3},
  pages={360-4}
}
BACKGROUND AND PURPOSE Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been suggested to be a useful method for detecting tumor hypoxia. In this study, we investigated whether DCE-MRI can differentiate between hypoxic and non-hypoxic experimental tumors. MATERIALS AND METHODS Three tumor models with hypoxic tissue and three tumor models without hypoxic tissue were subjected to DCE-MRI. Parametric images of K(trans) (the volume transfer constant of Gd-DTPA) and v(e) (the… CONTINUE READING