Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.

@article{Cuppoletti2014DifferentiationBH,
  title={Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.},
  author={John Cuppoletti and Jayati Chakrabarti and Kirti P. Tewari and Danuta H. Malinowska},
  journal={American journal of physiology. Cell physiology},
  year={2014},
  volume={307 5},
  pages={
          C479-92
        }
}
It has been difficult to separate/identify the roles of ClC-2 and CFTR in Cl(-) transport studies. Using pharmacological agents, we aimed to differentiate functionally between ClC-2 and CFTR Cl(-) channel currents. Effects of CFTR inhibitor 172 (CFTRinh172), N-(4-methylphenylsulfonyl)-N'-(4-trifluoromethylphenyl)urea (DASU-02), and methadone were examined by whole cell patch clamp on Cl(-) currents in recombinant human ClC-2/human embryonic kidney 293 (ClC-2/HEK293) cells stably transformed… 
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