Differentiation-associated miR-22 represses Max expression and inhibits cell cycle progression.

  title={Differentiation-associated miR-22 represses Max expression and inhibits cell cycle progression.},
  author={Yi Tian Ting and Daniel J. Medina and Roger Strair and Dale G Schaar},
  journal={Biochemical and biophysical research communications},
  volume={394 3},
Differentiation agents such as 12-O-tetradecanoylphorbol-13-acetate (TPA) engage cell signaling pathways that activate downstream transcriptional programs necessary for cell differentiation. Recent evidence has indicated microRNAs (miRNAs) are an integral part of these transcriptional programs, which target key proteins and impact cell growth thereby facilitating changes required for differentiation. To further investigate the role of miRNAs in cell growth and differentiation, we focused on miR… CONTINUE READING


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