Differentiation arrest by autologously replicating DNA loops formed along differentiation pathway: an hypothesis of carcinogenesis.


The current hypothesis attempts to explain tumor development from the perspective of deoxyribonucleic acid structural changes rather than mutational alterations of single or multiple genes. The hypothesis postulates that stable deoxyribonucleic acid loops capable of autologous replication, translation and expression cause cell-differentiation arrest and… (More)


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