Differentiation and migration of neural crest stem cells are stimulated by pancreatic islets

@article{Kozlova2009DifferentiationAM,
  title={Differentiation and migration of neural crest stem cells are stimulated by pancreatic islets},
  author={Elena N. Kozlova and Leif Jansson},
  journal={NeuroReport},
  year={2009},
  volume={20},
  pages={833-838}
}
Neural crest stem cells (NCSCs) migrate during embryonic development towards the endoderm-derived pancreas and the interaction between NCSCs and &bgr;-cell progenitors is crucial for their mutual differentiation. In diabetes, loss of &bgr;-cells or impaired &bgr;-cell function is accompanied by nerve degeneration, which contributes to the progression of the disease. Here we show that adult pancreatic islets markedly promote differentiation of NCSCs towards neuronal phenotype in vitro and in… CONTINUE READING
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