Differentiation and migration of Sca1+/CD31- cardiac side population cells in a murine myocardial ischemic model.

@article{Liang2010DifferentiationAM,
  title={Differentiation and migration of Sca1+/CD31- cardiac side population cells in a murine myocardial ischemic model.},
  author={Simon Xun Liang and Terence Y L Tan and Leonie Gaudry and Beng Hock Chong},
  journal={International journal of cardiology},
  year={2010},
  volume={138 1},
  pages={40-9}
}
BACKGROUND Side population cells are a rare subset of cells found in the adult heart that are highly enriched for stem and progenitor cell activity. Recent studies have suggested that Sca1+/CD31- cardiac side population cells are capable of differentiation into cardiomyocytes in vitro. However, the response of these cells to myocardial injury remains unknown in vivo. METHODS Sca1+/CD31- cardiac side population cells were isolated from mouse (C57BL6/J) hearts by FACS. These cells were labeled… CONTINUE READING
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