Differentiation and functional analysis of human T(H)17 cells.

  title={Differentiation and functional analysis of human T(H)17 cells.},
  author={Simone Burgler and Nadia Ouaked and Claudio Bassin and Tomasz M. Basinski and P Y Mantel and Kerstin Siegmund and Norbert Meyer and Cezmi A. Akdis and Carsten B. Schmidt-Weber},
  journal={The Journal of allergy and clinical immunology},
  volume={123 3},
  pages={588-95, 595.e1-7}
BACKGROUND T(H)17 cells are of pathologic relevance in autoimmune disorders and presumably also in allergy and asthma. Regulatory T (Treg) cells, in contrast, suppress inflammatory and allergen-driven responses. Despite these disparate functions, both T-cell subsets have been shown to be dependent on TGF-beta for their development. OBJECTIVE The aim of the study was to analyze the differentiation and function of human T(H)17 cells in comparison with other T(H) cell subsets. METHODS Naive… CONTINUE READING
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IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

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