Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms.

@article{Haagensen2007DifferentiationAD,
  title={Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms.},
  author={Janus Haagensen and Mikkel Klausen and Robert K Ernst and Samuel I. Miller and Anders Folkesson and Tim Tolker-Nielsen and Soeren Molin},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 1},
  pages={28-37}
}
During Pseudomonas aeruginosa flow cell biofilm development, the cell population differentiates into a nonmotile subpopulation which forms microcolonies and a migrating subpopulation which eventually colonizes the top of the microcolonies, resulting in the development of mushroom-shaped multicellular structures. The cap-forming subpopulation was found to develop tolerance to membrane-targeting antimicrobial agents, such as the cyclic cationic peptide colistin and the detergent sodium dodecyl… CONTINUE READING
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