Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells.

Abstract

Human embryonic stem cells (hESCs) may provide a cell source for functional hepatocytes for clinical applications and drug development. Initially, the hESC population was enriched to be more than 85% definitive endoderm (DE) as assessed by the expression of CXCR4, SOX17, and FOXA2. We then successfully converted DE into hepatic progenitors with 93% of the… (More)
DOI: 10.1002/stem.315

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