Corpus ID: 87106191

Differentiation Enhancement of ADSC in Scaffolds With IGF-1 Gene Impregnation Under Dynamic Microenvironment

  title={Differentiation Enhancement of ADSC in Scaffolds With IGF-1 Gene Impregnation Under Dynamic Microenvironment},
  author={Zhu Yan},
  journal={Progress in Biochemistry and Biophysics},
  • Zhu Yan
  • Published 2009
  • Biology
  • Progress in Biochemistry and Biophysics
Biochemical and mechanical signals enabling cardiac regeneration can be elucidated by using in vitro tissue engineering models. It was hypothesized that human insulin-like growth factor-1 (IGF-1) and three dimensional dynamic microenvironment could act independently and interactively to enhance the survival and differentiation of adipose tissue-derived stem cells (ADSCs) and hence the construction of engineered cardiac grafts. IGF-1 can be expressed by the ADSCs through genetic modification… Expand
2 Citations
Insulin-like growth factor-I and slow, bi-directional perfusion enhance the formation of tissue-engineered cardiac grafts.
It is demonstrated that multi-factorial stimulation of tissue-engineered cardiac grafts using IGF and perfusion resulted in independent and interactive effects on heart cell survival, differentiation, and contractility. Expand
Scaffold-free human cardiac tissue patch created from embryonic stem cells.
These novel scaffold-free human myocardial patches address critical challenges related to human cell sourcing and tissue fabrication that previously inhibited progress in cardiac tissue engineering. Expand