Differentiation‐associated surface antigen variation in the ancient eukaryote Giardia lamblia

  title={Differentiation‐associated surface antigen variation in the ancient eukaryote Giardia lamblia},
  author={S. Sv{\"a}rd and T. Meng and M. Hetsko and J. McCaffery and F. Gillin},
  journal={Molecular Microbiology},
  • S. Svärd, T. Meng, +2 authors F. Gillin
  • Published 1998
  • Biology, Medicine
  • Molecular Microbiology
  • Encystation of Giardia lamblia is required for survival outside the host, whereas excystation initiates infection. The dormant cyst was considered an adaptation to external survival and passage through the stomach. However, we found previously that trophozoites which had recovered after completion of the life cycle had switched their major variant surface protein (VSP), called TSA 417, but neither the timing nor the molecular mechanism of switching had been elucidated. Here we demonstrate that… CONTINUE READING
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