Differentiation‐associated surface antigen variation in the ancient eukaryote Giardia lamblia
@article{Svrd1998DifferentiationassociatedSA, title={Differentiation‐associated surface antigen variation in the ancient eukaryote Giardia lamblia}, author={S. Sv{\"a}rd and T. Meng and M. Hetsko and J. McCaffery and F. Gillin}, journal={Molecular Microbiology}, year={1998}, volume={30} }
Encystation of Giardia lamblia is required for survival outside the host, whereas excystation initiates infection. The dormant cyst was considered an adaptation to external survival and passage through the stomach. However, we found previously that trophozoites which had recovered after completion of the life cycle had switched their major variant surface protein (VSP), called TSA 417, but neither the timing nor the molecular mechanism of switching had been elucidated. Here we demonstrate that… CONTINUE READING
Topics from this paper
76 Citations
Proteomics of Secretory and Endocytic Organelles in Giardia lamblia
- Biology, Medicine
- PloS one
- 2014
- 34
- PDF
Export of cyst wall material and Golgi organelle neogenesis in Giardia lamblia depend on endoplasmic reticulum exit sites
- Biology, Medicine
- Cellular microbiology
- 2013
- 20
Surface antigenic variation in Giardia lamblia
- Biology, Medicine
- Molecular microbiology
- 2002
- 128
- Highly Influenced
Mining the Giardia lamblia Genome for New Cyst Wall Proteins*
- Medicine, Biology
- Journal of Biological Chemistry
- 2003
- 101
- PDF
The Giardia lamblia vsp gene repertoire: characteristics, genomic organization, and evolution
- Biology, Medicine
- BMC Genomics
- 2010
- 70
References
SHOWING 1-10 OF 54 REFERENCES
Giardia lamblia: traffic of a trophozoite variant surface protein and a major cyst wall epitope during growth, encystation, and antigenic switching.
- Biology, Medicine
- Experimental parasitology
- 1994
- 69
Cellular and transcriptional changes during excystation of Giardia lamblia in vitro.
- Biology, Medicine
- Experimental parasitology
- 1998
- 66
Proteolytic release of cell surface proteins during differentiation of Trypanosoma brucei.
- Biology, Medicine
- Biochemistry
- 1993
- 52
Developmentally regulated transcripts and evidence of differential mRNA processing in Giardia lamblia.
- Biology, Medicine
- Molecular and biochemical parasitology
- 1996
- 43
Transcriptional regulation of metacyclic variant surface glycoprotein gene expression during the life cycle of Trypanosoma brucei.
- Biology, Medicine
- Molecular and cellular biology
- 1995
- 56
- PDF
Stage-specific mechanisms for activation and expression of variant surface glycoprotein genes in Trypanosoma brucei.
- Biology, Medicine
- Biochemical Society transactions
- 1990
- 17
- PDF
Analysis of Trypanosoma brucei vsg expression site switching in vitro.
- Biology, Medicine
- Molecular and biochemical parasitology
- 1997
- 69
- Highly Influential
- PDF
Antigenic switching of TSA 417, a trophozoite variable surface protein, following completion of the life cycle of Giardia lamblia.
- Biology, Medicine
- Infection and immunity
- 1993
- 23
- PDF
Genetic controls for the expression of surface antigens in African trypanosomes.
- Biology, Medicine
- Annual review of microbiology
- 1994
- 136
- Highly Influential