• DOI:10.1046/j.1365-2958.1998.01125.x
Corpus ID: 26329209

Differentiation‐associated surface antigen variation in the ancient eukaryote Giardia lamblia

@article{Svrd1998DifferentiationassociatedSA,
  title={Differentiation‐associated surface antigen variation in the ancient eukaryote Giardia lamblia},
  author={S. Sv{\"a}rd and T. Meng and M. Hetsko and J. McCaffery and F. Gillin},
  journal={Molecular Microbiology},
  year={1998},
  volume={30}
}

S. Svärd, T. Meng, +2 authors F. Gillin

Published 1998

Biology, Medicine

Molecular Microbiology

Encystation of Giardia lamblia is required for survival outside the host, whereas excystation initiates infection. The dormant cyst was considered an adaptation to external survival and passage through the stomach. However, we found previously that trophozoites which had recovered after completion of the life cycle had switched their major variant surface protein (VSP), called TSA 417, but neither the timing nor the molecular mechanism of switching had been elucidated. Here we demonstrate that… CONTINUE READING

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