Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease.

@article{Li2007DifferentiationSA,
  title={Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease.},
  author={Zongjin Li and J C Gaston Wu and Ahmad Yahya Sheikh and Daniel L. Kraft and Feng Cao and Xiaoyan Xie and Manishkumar Chandrasen Patel and Sanjiv Sam Gambhir and Robert Clayton Robbins and John P Cooke and Joseph C Wu},
  journal={Circulation},
  year={2007},
  volume={116 11 Suppl},
  pages={
          I46-54
        }
}
BACKGROUND Embryonic stem (ES) cells are distinguished by their capacity for self-renewal and pluripotency. Here we characterize the differentiation of ES cell-derived endothelial cells (ESC-ECs), use molecular imaging techniques to examine their survival in vivo, and determine the therapeutic efficacy of ESC-ECs for restoration of cardiac function after ischemic injury. METHODS AND RESULTS Murine ES cells were transfected with a construct composed of a vascular endothelial cadherin promoter… CONTINUE READING
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