Differentiation, phenotype, and function of interleukin-17-producing human Vγ9Vδ2 T cells.

  title={Differentiation, phenotype, and function of interleukin-17-producing human V$\gamma$9V$\delta$2 T cells.},
  author={Nadia Caccamo and Carmela La Mendola and Valentina Orlando and Serena Meraviglia and Matilde Todaro and Giorgio Stassi and Guido Sireci and Jean-Jacques Fourni{\'e} and Francesco Dieli},
  volume={118 1},
In healthy adults, the major peripheral blood γδ T-cell subset expresses the Vγ9Vδ2 TCR and displays pleiotropic features. Here we report that coculture of naive Vγ9Vδ2 T cells with phosphoantigens and a cocktail of cytokines (IL-1-β, TGF-β, IL-6, and IL-23), leads to selective expression of the transcription factor RORγt and polarization toward IL-17 production. IL-17(+) Vγ9Vδ2 T cells express the chemokine receptor CCR6 and produce IL-17 but neither IL-22 nor IFN-γ; they have a predominant… 

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