Differentiation, extracellular matrix synthesis, and integrin assembly by Drosophila embryo cells cultured on vitronectin and laminin substrates.

@article{Gullberg1994DifferentiationEM,
  title={Differentiation, extracellular matrix synthesis, and integrin assembly by Drosophila embryo cells cultured on vitronectin and laminin substrates.},
  author={Donald Gullberg and Liselotte I. Fessler and John H. Fessler},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1994},
  volume={199 2},
  pages={116-28}
}
Two contrasting substrates, Drosophila laminin and human vitronectin, caused determined primary Drosophila embryo cells to follow alternate intermediate differentiation steps without affecting the final outcome of differentiation. Integrin alpha PS2 beta PS3 was essential for the initial spreading of myocytes on vitronectin: focal contacts rich in beta PS3 integrins formed and were connected by actin- and myosin-containing stress fibers. While alpha PS2 beta PS3 was unnecessary for myotube… CONTINUE READING

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