Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma.

@article{Spees2003DifferentiationCF,
  title={Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma.},
  author={Jeffrey L. Spees and Scott D Olson and Joni Ylostalo and Patrick J. Lynch and Jason Smith and Anthony J Perry and Alexandra Peister and Meng Yu Wang and D. J. Prockop},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 5},
  pages={2397-402}
}
To investigate stem cell differentiation in response to tissue injury, human mesenchymal stem cells (hMSCs) were cocultured with heat-shocked small airway epithelial cells. A subset of the hMSCs rapidly differentiated into epithelium-like cells, and they restored the epithelial monolayer. Immunocytochemistry and microarray analyses demonstrated that the cells expressed many genes characteristic of normal small airway epithelial cells. Some hMSCs differentiated directly after incorporation into… CONTINUE READING
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