Differentiating the pathologies of cerebral malaria by postmortem parasite counts

  title={Differentiating the pathologies of cerebral malaria by postmortem parasite counts},
  author={Terrie E. Taylor and Wenjiang J. Fu and Richard Allen Carr and Richard O. Whitten and Jeffrey G. Mueller and Nedson G Fosiko and S. Lewallen and N. George Liomba and Malcolm Edward Molyneux},
  journal={Nature Medicine},
To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical… CONTINUE READING
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