Differentiating the effects of centrally acting drugs on arousal and memory: an event-related potential study of scopolamine, lorazepam and diphenhydramine

@article{Curran1998DifferentiatingTE,
  title={Differentiating the effects of centrally acting drugs on arousal and memory: an event-related potential study of scopolamine, lorazepam and diphenhydramine},
  author={H. Valerie Curran and P. Pooviboonsuk and J. A. Dalton and Malcolm Harold Lader},
  journal={Psychopharmacology},
  year={1998},
  volume={135},
  pages={27-36}
}
Abstract The degree to which apparent amnesic effects of various centrally acting drugs are secondary to their effects on arousal remains a contentious issue. The present study uses two methods to dissociate memory and arousal effects of the cholinergic antagonist, scopolamine (SP), and the GABA-A/benzodiazepine receptor agonist, lorazepam (LZ). First, it compared their effects to those of an antihistamine, diphenhydramine (DPh), to provide an active control for arousal reduction. Second, it… 
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