Differentiating factors between erythropoiesis-stimulating agents: a guide to selection for anaemia of chronic kidney disease.

@article{Deicher2004DifferentiatingFB,
  title={Differentiating factors between erythropoiesis-stimulating agents: a guide to selection for anaemia of chronic kidney disease.},
  author={Robert Deicher and Walter Hermann H{\"o}rl},
  journal={Drugs},
  year={2004},
  volume={64 5},
  pages={499-509}
}
Endogenous erythropoietin (EPO) consists of a central polypeptide core covered by post-translationally linked carbohydrates. Three of the four currently available erythropoiesis stimulating agents (ESA)--epoetin-alpha, epoetin-beta and epoetin-omega- are composed of an identical amino acid sequence, but glycosylation varies as a result of type- and host cell-specific differences in the production process. Epoetin-alpha and epoetin-beta resemble each other with respect to molecular… CONTINUE READING
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