Differentiating between Near- and Non-Cognate Codons in Saccharomyces cerevisiae

  title={Differentiating between Near- and Non-Cognate Codons in Saccharomyces cerevisiae},
  author={Ewan P Plant and Phuc Hong Nguyen and Jonathan R. Russ and Yvette R. Pittman and Thai Ha Nguyen and Jack T. Quesinberry and Terri Goss Kinzy and Jonathan D. Dinman},
  journal={PLoS ONE},
  pages={548 - 555}
BACKGROUND Decoding of mRNAs is performed by aminoacyl tRNAs (aa-tRNAs). This process is highly accurate, however, at low frequencies (10(-3) - 10(-4)) the wrong aa-tRNA can be selected, leading to incorporation of aberrant amino acids. Although our understanding of what constitutes the correct or cognate aa-tRNA:mRNA interaction is well defined, a functional distinction between near-cognate or single mismatched, and unpaired or non-cognate interactions is lacking. METHODOLOGY/PRINCIPAL… CONTINUE READING
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