Differentiated adipose-derived stem cells promote myelination and enhance functional recovery in a rat model of chronic denervation.

@article{Tomita2012DifferentiatedAS,
  title={Differentiated adipose-derived stem cells promote myelination and enhance functional recovery in a rat model of chronic denervation.},
  author={Koichi Tomita and Tomas Madura and Cristina M Mantovani and Giorgio Terenghi},
  journal={Journal of neuroscience research},
  year={2012},
  volume={90 7},
  pages={1392-402}
}
Transplantation of autologous Schwann cells (SCs) is a promising approach for treating various peripheral nerve disorders, including chronic denervation. However, given their drawbacks, such as invasive biopsy and lengthy culture in vitro, alternative cell sources would be needed. Adipose-derived stem cells (ASCs) are a candidate, and in this study rat ASCs transdifferentiated into a SC phenotype (dASC) cocultured with dorsal root ganglion neurons were shown to associate with neurites and to… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
18 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

: autologous Schwann cells vs . transdifferentiated mesenchymal stem cells

  • PJ Kingham, DF Kalbermatten, D Mahay, SJ Armstrong, M Wiberg, G Terenghi
  • 2007
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…