Differentiated Mesenchymal Stem Cells for Sciatic Nerve Injury

  title={Differentiated Mesenchymal Stem Cells for Sciatic Nerve Injury},
  author={Michal Dadon-Nachum and Ofer Sadan and Itay Srugo and Eldad Melamed and Daniel Offen},
  journal={Stem Cell Reviews and Reports},
Sciatic nerve injury is common and may cause neurological deficits. Previous studies showed that administration of neurotrophic factors (NTFs), naturally occurring proteins that support the development and survival of neurons, preserved and protected damaged motor neuron in the injured sciatic nerve. We have been successful in converting bone marrow-derived mesenchymal stem cells into astrocyte-like cells that produce and secrete NTFs (NTF+ cells). These cells demonstrate typical astrocyte… CONTINUE READING
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