• Biology, Medicine
  • Published in Anticancer research 1996

Differentially spliced exon 5 of the Wilms' tumor gene WT1 modifies gene function.

@article{Hewitt1996DifferentiallySE,
  title={Differentially spliced exon 5 of the Wilms' tumor gene WT1 modifies gene function.},
  author={Stephen M. Hewitt and Grady Franklin Saunders},
  journal={Anticancer research},
  year={1996},
  volume={16 2},
  pages={
          621-6
        }
}
The Wilms' tumor gene WT1 encodes a zinc-finger transcription factor that functions as a tumor suppressor gene and repress transcription of a number of growth factors and proto-oncogenes. In the developing kidney, WT1 expression peaks at the onset of the mesenchyme-to-epithelium transition and is required for epithelial differentiation. WT1 mRNA undergoes alternative splicing at two sites, resulting in four mRNA species and proteins expressed in constant ratios. The first alternative splice… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Insights into the physiological role of WT1 from studies of genetically modified mice.

VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED