Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort.
@article{Cordero2015DifferentiallyMM, title={Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort.}, author={Francesca Cordero and Giulio Ferrero and Silvia Polidoro and Giovanni Fiorito and Gianluca Campanella and Carlotta Sacerdote and Amalia Mattiello and Giovanna Masala and Claudia Agnoli and Graziella Frasca and Salvatore Panico and Domenico Palli and Vittorio Krogh and Rosario Tumino and Paolo Vineis and Alessio Naccarati}, journal={Carcinogenesis}, year={2015}, volume={36 10}, pages={ 1144-53 } }
The crosstalk between microRNAs (miRNAs) and other epigenetic factors may lead to novel hypotheses about carcinogenesis identifying new targets for research. Because a single miRNA can regulate multiple downstream target genes, its altered expression may potentially be a sensitive biomarker to detect early malignant transformation and improve diagnosis and prognosis. In the current study, we tested the hypothesis that altered methylation of miRNA encoding genes, associated with deregulated…
30 Citations
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- 2021
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- 2016
Because ncRNAs are involved in regulating gene expression through interaction with epigenetic modifiers, their dysregulation appears causally related to epigenetic alterations in cancer.
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A ceRNA regulatory network of GC with Hp infection is successfully constructed, consisting of 10 lncRNAs, 11 miRNAs and 219 mRN as well as STRING database, which revealed that differentially expressed mRNAs involved in the ceRNA network were mainly involved in extracellular exosomes, structural molecular activities, proteolysis and P13K-Akt signaling pathways.
CMAR_A_244606 4677..4684
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- 2020
Retinoic acid receptor β (RARβ) is a tumor suppressor gene, and RARβ methylation has been found to be associated with cancers, including BC, and prior studies have shown that some individual lifestyle factors, such as smoking and diet, could affect RAR β methylation, although inconsistent data have been reported.
References
SHOWING 1-10 OF 52 REFERENCES
Circulating Micro-RNAs as Potential Blood-Based Markers for Early Stage Breast Cancer Detection
- Biology, MedicinePloS one
- 2012
MiRNA profiling in whole blood has potential as a novel method for early stage breast cancer detection, but there are still challenges that need to be addressed to establish these new biomarkers in clinical use.
Impact of Cellular miRNAs on Circulating miRNA Biomarker Signatures
- BiologyPloS one
- 2011
It is found that measurement of circulating miRNA levels are frequently confounded by varying levels of cellular miRNAs of different hematopoietic origins, and the intrinsic variability of circulate miRNA species investigated in subsets of healthy males and females.
Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer
- Biology, MedicineProceedings of the National Academy of Sciences
- 2013
The integrated RNA signature was successfully validated on eight BC cohorts, comprising a total of 2,399 patients, and it had superior performance for risk stratification with respect to other RNA predictors, including the mRNAs used in MammaPrint and Oncotype DX assays.
Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors
- BiologyGenome Biology
- 2013
The study contributes to the understanding of how methylation and copy number alterations influence miRNA expression, emphasizing miRNA functionality through redundant encoding, and suggests novel miRNAs important in breast cancer.
Integrated Epigenetics of Human Breast Cancer: Synoptic Investigation of Targeted Genes, MicroRNAs and Proteins upon Demethylation Treatment
- BiologyPloS one
- 2011
A synoptic model is investigated to predict complete DAC treatment effects at the level of genes, microRNAs and proteins for several human breast cancer lines and shows significant dysregulation of some important oncogenes, oncomiRs and oncosuppressors miRNAs as well as drug tolerance genes/miRNAs/proteins.
Genome-wide aberrant DNA methylation of microRNA host genes in hepatocellular carcinoma
- BiologyEpigenetics
- 2012
Test the hypothesis that DNA methylation alterations in miRNA host genes may cause deregulated miRNA expression in HCC by analyzing tumor and adjacent non-tumor tissues with Infinium HumanMethylation27 DNA Analysis BeadChips and data suggest that aberrant DNAmethylation may lead to dysregulation of miR-10a in H CC tumor tissues.
Epigenetic inactivation of microRNA gene hsa‐mir‐9‐1 in human breast cancer
- BiologyThe Journal of pathology
- 2008
It is demonstrated that various microRNA genes are also affected by epigenetic inactivation due to aberrant hypermethylation and that this is an early and frequent event in breast cancer development.
Epigenetic epidemiology of cancer.
- BiologyBiochemical and biophysical research communications
- 2014
Analysis of serum genome-wide microRNAs for breast cancer detection.
- BiologyClinica chimica acta; international journal of clinical chemistry
- 2012
DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer
- BiologyOncogene
- 2012
Even at this early stage, the transcriptional repression of miRNAs by hypermethylation of their corresponding promoter loci seems to be a common feature of all human tumors, which will have translational consequences for the management of the disease.