Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort.

@article{Cordero2015DifferentiallyMM,
  title={Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort.},
  author={Francesca Cordero and Giulio Ferrero and Silvia Polidoro and Giovanni Fiorito and Gianluca Campanella and Carlotta Sacerdote and Amalia Mattiello and Giovanna Masala and Claudia Agnoli and Graziella Frasca and Salvatore Panico and Domenico Palli and Vittorio Krogh and Rosario Tumino and Paolo Vineis and Alessio Naccarati},
  journal={Carcinogenesis},
  year={2015},
  volume={36 10},
  pages={
          1144-53
        }
}
The crosstalk between microRNAs (miRNAs) and other epigenetic factors may lead to novel hypotheses about carcinogenesis identifying new targets for research. Because a single miRNA can regulate multiple downstream target genes, its altered expression may potentially be a sensitive biomarker to detect early malignant transformation and improve diagnosis and prognosis. In the current study, we tested the hypothesis that altered methylation of miRNA encoding genes, associated with deregulated… 

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CMAR_A_244606 4677..4684

Retinoic acid receptor β (RARβ) is a tumor suppressor gene, and RARβ methylation has been found to be associated with cancers, including BC, and prior studies have shown that some individual lifestyle factors, such as smoking and diet, could affect RAR β methylation, although inconsistent data have been reported.

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