Differentially expressed protein profile of renal tubule cell stimulated by elevated uric acid using SILAC coupled to LC-MS.

@article{Quan2011DifferentiallyEP,
  title={Differentially expressed protein profile of renal tubule cell stimulated by elevated uric acid using SILAC coupled to LC-MS.},
  author={Hong Ping Quan and Xue Peng and Shuwen Liu and Fu Bo and Lv Yang and Zhiyong Huang and Haixia Li and Xiangmei Chen and Wu Di},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2011},
  volume={27 1},
  pages={
          91-8
        }
}
BACKGROUND/AIMS Hyperuricemia could lead to serious renal disease. It will advance our understanding of the mechanism of this disease to study the differentially expressed protein in renal tubular epithelial cells stimulated by elevated uric acid. METHODS We used SILAC coupled to LC-MS to study differentially expressed protein profile and to analysis the functional status of renal tubular epithelial cells stimulated by 600μM uric acid, and to investigate the potential biology function. The MS… CONTINUE READING

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