Differentially expressed messenger RNA isoforms of the human estrogen receptor-alpha gene are generated by alternative splicing and promoter usage.

@article{Flouriot1998DifferentiallyEM,
  title={Differentially expressed messenger RNA isoforms of the human estrogen receptor-alpha gene are generated by alternative splicing and promoter usage.},
  author={Gilles Flouriot and Caroline Griffin and Mary-Rose Kenealy and Vera Sonntag-Buck and Frank Gannon},
  journal={Molecular endocrinology},
  year={1998},
  volume={12 12},
  pages={1939-54}
}
The isolation and characterization of several new human estrogen receptor-alpha (hERalpha) mRNAs are described. Together with those previously identified, they give rise to a total of six hERalpha mRNA isoforms (A-F hERalpha mRNAs). Produced from a single hERalpha gene by multiple promoter usage, all these transcripts encode a common protein but differ in their 5'-untranslated region as a consequence of alternative splicing of five upstream exons (1B-1F). RT-PCR and S1 nuclease mapping analysis… CONTINUE READING

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