Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways

@article{Zhang2014DifferentiallyCG,
  title={Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways},
  author={Huiping Zhang and Fan Wang and Hongqin Xu and Yawen Liu and Jin Liu and Hongyu Zhao and Joel Gelernter},
  journal={Human Genetics},
  year={2014},
  volume={133},
  pages={1383-1394}
}
Chronic alcohol consumption may induce gene expression alterations in brain reward regions such as the prefrontal cortex (PFC), modulating the risk of alcohol use disorders (AUDs). Transcriptome profiles of 23 AUD cases and 23 matched controls (16 pairs of males and 7 pairs of females) in postmortem PFC were generated using Illumina’s HumanHT-12 v4 Expression BeadChip. Probe-level differentially expressed genes and gene modules in AUD subjects were identified using multiple linear regression… CONTINUE READING
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