Differentially Timed Extracellular Signals Synchronize Pacemaker Neuron Clocks

  title={Differentially Timed Extracellular Signals Synchronize Pacemaker Neuron Clocks},
  author={Ben Collins and Harris S Kaplan and Matthieu Cavey and Katherine R. Lelito and Andrew Bahle and Zhonghua Zhu and Ann Marie Macara and Gregg Roman and Orie Thomas Shafer and Justin Blau and Paul H Taghert},
  booktitle={PLoS biology},
Synchronized neuronal activity is vital for complex processes like behavior. Circadian pacemaker neurons offer an unusual opportunity to study synchrony as their molecular clocks oscillate in phase over an extended timeframe (24 h). To identify where, when, and how synchronizing signals are perceived, we first studied the minimal clock neural circuit in Drosophila larvae, manipulating either the four master pacemaker neurons (LNvs) or two dorsal clock neurons (DN1s). Unexpectedly, we found that… CONTINUE READING
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