Differential withdrawal of retinal axons induced by a secreted factor.

  title={Differential withdrawal of retinal axons induced by a secreted factor.},
  author={Hiroyuki Ichijo and Friedrich Bonhoeffer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={18 13},
To understand the development of the topographic map in the chick retinotectal projection, we studied the long-term interactions between retinal axons and tectal cell processes using a novel coculture system, the ryomen chamber. Both nasal and temporal retinal axons initially grew equally well on a substrate consisting of posterior tectal cell processes; however, subsequently most temporal axons withdrew from this surface, whereas most nasal axons did not. Experiments using conditioned media… CONTINUE READING
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