Differential wiring of layer 2/3 neurons drives sparse and reliable firing during neocortical development.

@article{Benedetti2013DifferentialWO,
  title={Differential wiring of layer 2/3 neurons drives sparse and reliable firing during neocortical development.},
  author={Brett L. Benedetti and Yoshio Takashima and Jing A. Wen and Joanna Urban-Ciecko and Alison L. Barth},
  journal={Cerebral cortex},
  year={2013},
  volume={23 11},
  pages={2690-9}
}
Sensory information is transmitted with high fidelity across multiple synapses until it reaches the neocortex. There, individual neurons exhibit enormous variability in responses. The source of this diversity in output has been debated. Using transgenic mice expressing the green fluorescent protein coupled to the activity-dependent gene c-fos, we identified neurons with a history of elevated activity in vivo. Focusing on layer 4 to layer 2/3 connections, a site of strong excitatory drive at an… CONTINUE READING

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