Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels.

@article{Jo2016DifferentialVR,
  title={Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels.},
  author={Andrew O. Jo and M{\'o}nika Lakk and Amber M Frye and Tam Thi Thanh Phuong and Sarah N. Redmon and Robin Michael Roberts and Bruce A. Berkowitz and Oleg Yarishkin and David Kri{\vz}aj},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 14},
  pages={3885-90}
}
Fluid secretion by the ciliary body plays a critical and irreplaceable function in vertebrate vision by providing nutritive support to the cornea and lens, and by maintaining intraocular pressure. Here, we identify TRPV4 (transient receptor potential vanilloid isoform 4) channels as key osmosensors in nonpigmented epithelial (NPE) cells of the mouse ciliary body. Hypotonic swelling and the selective agonist GSK1016790A (EC50 ∼33 nM) induced sustained transmembrane cation currents and cytosolic… CONTINUE READING
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