Differential variation of mitochondrial H2O2 release during aging in oxidative and glycolytic muscles in rats.

@article{Capel2004DifferentialVO,
  title={Differential variation of mitochondrial H2O2 release during aging in oxidative and glycolytic muscles in rats.},
  author={Fr{\'e}d{\'e}ric Capel and Caroline Buffi{\`e}re and Philippe Patureau Mirand and Laurent Mosoni},
  journal={Mechanisms of ageing and development},
  year={2004},
  volume={125 5},
  pages={367-73}
}
Mitochondrial free radical (ROS) production could be involved in sarcopenia. Our aim was to measure this production in various muscles during aging. Male Wistar rats aged 4.5 and 24 months were used. H(2)O(2) release and protein carbonyls were evaluated in isolated mitochondria from an oxidative (soleus) and a glycolytic (tibialis anterior) muscle. Total and Mn-superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX) and glutathione reductase (GR) activities were measured in tibialis… CONTINUE READING
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