Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity.

@article{Cho1988DifferentialUO,
  title={Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity.},
  author={Ken W.Y Cho and J{\"u}rgen G{\"o}tz and Christopher V E Wright and Anna Fritz and Jim Hardwicke and Eddy M De Robertis},
  journal={The EMBO journal},
  year={1988},
  volume={7 7},
  pages={2139-49}
}
Xenopus XlHbox 1 produces two transcripts during early development. One encodes a long open reading frame (ORF) and the other a short ORF sharing the same homeodomain, but differing by an 82 amino acid domain at the amino terminus. The long protein amino terminus is conserved with many other homeodomain proteins, and its absence from the short protein could have functional consequences. Some viral genes also utilize a single ORF to encode transcription factors of antagonistic functions. The… CONTINUE READING

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