Differential utilization of systemic and enteral ammonia for urea synthesis in control subjects and ornithine transcarbamylase deficiency carriers.

@article{Scaglia2003DifferentialUO,
  title={Differential utilization of systemic and enteral ammonia for urea synthesis in control subjects and ornithine transcarbamylase deficiency carriers.},
  author={Fernando Scaglia and Juan C. Marini and Judy Rosenberger and Joseph Henry and Peter Garlick and Brendan Lee and Peter J. Reeds},
  journal={The American journal of clinical nutrition},
  year={2003},
  volume={78 4},
  pages={749-55}
}
BACKGROUND Female carriers of ornithine transcarbamylase deficiency (OTCD) have nearly normal rates of total urea synthesis, but they derive less urea from systemic glutamine amide nitrogen than do healthy persons. OBJECTIVE The objective of the study was to investigate whether females with symptomatic OTCD rely on alternative pathways to compensate for the reduced urea synthesis activity observed in this disorder. DESIGN The 5-d study involved 6 control subjects (3 males, 3 females) and 6… CONTINUE READING
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