Differential utilization of poly(rC) binding protein 2 in translation directed by picornavirus IRES elements.

@article{Walter1999DifferentialUO,
  title={Differential utilization of poly(rC) binding protein 2 in translation directed by picornavirus IRES elements.},
  author={Brandon L Walter and Joseph H. C. Nguyen and Ellie Ehrenfeld and Bert L Semler},
  journal={RNA},
  year={1999},
  volume={5 12},
  pages={1570-85}
}
The translation of picornavirus genomic RNAs occurs by a cap-independent mechanism that requires the formation of specific ribonucleoprotein complexes involving host cell factors and highly structured regions of picornavirus 5' noncoding regions known as internal ribosome entry sites (IRES). Although a number of cellular proteins have been shown to be involved in picornavirus RNA translation, the precise role of these factors in picornavirus internal ribosome entry is not understood. In this… CONTINUE READING
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