Differential usage of the carboxyl-terminal region among aldolase isozymes.

@article{Berthiaume1993DifferentialUO,
  title={Differential usage of the carboxyl-terminal region among aldolase isozymes.},
  author={L M Berthiaume and Dean R. Tolan and Jurgen Sygusch},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 15},
  pages={10826-35}
}
Sequence homology among nonconserved residues 357-362 of the COOH-terminal region in fructose-1,6-bisphosphate aldolases correlates with isozyme classification of aldolases. Recombinant chimers of human liver and maize aldolases were constructed by exchanging residues 357-362 with those from muscle, maize, and liver isozyme and by insertion in the maize sequence at position 349 rabbit muscle and liver residues 346-349. Activity variation among the chimers relative to native controls ranged from… CONTINUE READING