Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.

@article{Sonoda2006DifferentialUO,
  title={Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.},
  author={Eiichiro Sonoda and Helfrid Hochegger and Alihossein Saberi and Yoshihito Taniguchi and Shunichi Takeda},
  journal={DNA repair},
  year={2006},
  volume={5 9-10},
  pages={1021-9}
}
Repair of DNA double strand breaks (DSBs) plays a critical role in the maintenance of the genome. DSB arise frequently as a consequence of replication fork stalling and also due to the attack of exogenous agents. Repair of broken DNA is essential for survival. Two major pathways, homologous recombination (HR) and non-homologous end-joining (NHEJ) have evolved to deal with these lesions, and are conserved from yeast to vertebrates. Despite the conservation of these pathways, their relative… CONTINUE READING
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