Differential transport requirements of HLA and H-2 class I glycoproteins

  title={Differential transport requirements of HLA and H-2 class I glycoproteins},
  author={Jeff Alexander and John A. Payne and Richard C. Murray and Jeffrey A Frelinger and Peter Cresswell},
Transport of human and mouse major histocompatibility complex class I glycoproteins has been examined in a transport deficient B-lymphoblastoid cell line × T-lymphoblastoid cell line (B-LCL × T-LCL) hybrid, 174 × CEM. T2 (T2). This cell line expresses no detectable endogenous HLA-B5 and reduced levels of HLA-A2 on its surface although these molecules are synthesized. In order to study this defect further, either HLA-Bw58 or HLA-B7 genomic clones were transfected into T2. Metabolic labeling and… CONTINUE READING
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