Differential translocation of heat shock factor-1 after mild and severe stress to human skin fibroblasts undergoing aging in vitro

@article{Demirovic2014DifferentialTO,
  title={Differential translocation of heat shock factor-1 after mild and severe stress to human skin fibroblasts undergoing aging in vitro},
  author={Dino Demirovic and I. M. D. Toda and C. Nizard and S. Rattan},
  journal={Journal of Cell Communication and Signaling},
  year={2014},
  volume={8},
  pages={333-339}
}
Repeated exposure to mild heat shock (HS) has been shown to induce a wide range of health promoting hormetic effects in various biological systems, including human cells undergoing aging in vitro. In order to understand how cells distinguish between mild and severe stress, we have investigated the extent of early and immediate HS response by analyzing the nuclear translocation of the transcription factor heat shock factor-1 (HSF1), in serially passaged normal adult human facial skin fibroblasts… Expand
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