Differential translational effects of myristic acid and eicosapentaenoic acid on 3-hydroxy-3-methylglutaryl-CoA reductase from Reuber H35 hepatoma cells.

@article{GarcaPelayo2004DifferentialTE,
  title={Differential translational effects of myristic acid and eicosapentaenoic acid on 3-hydroxy-3-methylglutaryl-CoA reductase from Reuber H35 hepatoma cells.},
  author={M Carmen Garc{\'i}a-Pelayo and Eduardo Garc{\'i}a-Peregr{\'i}n and Marina Mart{\'i}nez-Cayuela},
  journal={Experimental biology and medicine},
  year={2004},
  volume={229 8},
  pages={
          781-6
        }
}
The mechanisms by which saturated and polyunsaturated fatty acids may exert their effects on levels of blood cholesterol and human atherosclerosis have not been fully established. In this work, we studied the translational effects of myristic (14:0) and eicosapentaenoic (20:5) acids on 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase from Reuber H35 hepatoma cells. This enzyme is an intrinsic membrane, 96-kDa protein whose proteolysis releases an enzymatically active, 52- to 56-kDa, soluble… CONTINUE READING