Differential transduction mechanisms underlying NaCl- and KCl-induced responses in mouse taste cells.

@article{Miyamoto2001DifferentialTM,
  title={Differential transduction mechanisms underlying NaCl- and KCl-induced responses in mouse taste cells.},
  author={Tamaki Miyamoto and Toshihiro Miyazaki and Rie Fujiyama and Yukio Okada and Toshihide Sato},
  journal={Chemical senses},
  year={2001},
  volume={26 1},
  pages={67-77}
}
The transduction mechanism of salt-induced responses of mouse taste cells was investigated using the patch clamp and the local stimulation techniques under quasi-natural conditions. Apically applied NaCl induced a voltage-independent current, which was partially suppressed by amiloride and Cd2+. In contrast, apically applied 0.5 M KCl induced an inwardly rectifying current (KCl-induced Iir). The KCl-induced Iir was unaffected by amiloride. The Iir was suppressed not only by external Ba2+ and Cs… CONTINUE READING